WebDec 1, 2024 · Bystander T cell activation reveals a role for T cell function that is independent of TCR signaling. This type of antigen-independent activation has been observed in inflammatory environments, including autoimmunity, cancer, and most commonly during infection 5, 6, 7, 8, 9. WebApr 7, 1997 · Bystander activation, i.e., activation of T cells specific for an antigen X during an immune response against antigen Y may occur during viral infections. However, the …
Bystander Activation of T Cells May Be Cause of Persistent Arthritis in …
WebApr 12, 2024 · Responses to cancer immunotherapy regimens depend on a number of factors, including the T cells and the cancer cells themselves. Here, Naulaerts et al. … WebNov 1, 2024 · Bystander activation of T cells can be beneficial to the host as these cells contribute to early pathogen clearance 2, 7, 9. However, bystander-activated T cells have also been shown to drive pathogenesis in the context of chronic infections 10, 14, 15. Thus, bystander-activated T cells appear to be a double-edged sword with benefits for the ... how to dial ext
Bystander T cell activation - Trends in Immunology
WebAntigen-specific T cells play a central role in the adaptive immune response and come in a wide range of phenotypes. T cell receptors (TCRs) mediate the antigen-specificities found in T cells. Importantly, high-throughput TCR sequencing provides a fingerprint which allows tracking of specific T cells and their clonal expansion in response to particular antigens. … WebApr 14, 2010 · Bystander activation of T cells was first described by Tough and Sprent, showing that different viruses, virus-mimetics such as poly (I:C) or bacterial products such as LPS induced IFN-α/β secretion, which led to the proliferation and expansion of unrelated (heterologous) polyclonal T cells 1, 2. WebNov 12, 2024 · However, the promotion of bystander CD8 T-cell responses is not a general attribute of costimulatory TNF receptor superfamily (TNFRSF) members, since CD27 signals enhanced antigen-specific CD8 T cells responses … how to dial england from australia