WebDec 20, 2024 · Intracerebroventricular injection of fibroblast growth factor 1 (FGF1) in a rat model of type 2 diabetes mellitus (T2DM) induces sustained remission of … WebMay 23, 2016 · Because measures of insulin secretion were made at a time when blood glucose levels were lower in mFGF1- than in veh-treated mice, however, it remains possible that an effect of centrally...
Salk researchers find a new route for regulating blood …
WebWe found that FGF1 enhanced the adipocyte mTORC2/Rictor signalling pathway to inhibit C-C chemokine ligand 2 (CCL2) production, the major cause of circulating monocytes infiltration, activation and proliferation of resident macrophages in adipose tissues. WebDec 6, 2024 · We report that although icv FGF1 injection delays the onset of β-cell dysfunction in these animals, it has no effect on either glucose-induced insulin secretion or insulin sensitivity. These observations suggest that FGF1 acts in the brain to stimulate insulin-independent glucose clearance. docking the iss
Molecule Produced in Fat Tissue Could Unlock New Approaches to Diabetes ...
WebMar 3, 2024 · FGF1 has an unique ability to lower blood glucose, and pharmacologically-relevant FGF1 (0.5 mg/kg) leads to impressive changes in several measurements, including blood glucose, nearly normalizing … WebMay 25, 2016 · The injection, a relatively low dose of a tissue growth factor protein called fibroblast growth factor 1 (FGF1), appears to reset powerful neural networks that can control the amount of sugar in... WebJan 7, 2024 · The FGF1 hormone regulates blood glucose by inhibiting fat breakdown, although it works differently than insulin. Investigators from Salk Institute have discovered a new molecule produced in fat tissue that could act similarly to insulin, rapidly regulating blood glucose levels. docking toolbar翻译