Web21 okt. 2013 · Following the dissolution, transfer, pH adjustment, and injection of 300 μL of hyperpolarized [1-13 C]pyruvate in 5 s, the acquisition was triggered by the polarizer electronics. The 13 C signals of [1-13 C]pyruvate and [1-13 C]lactate decayed with a time constant of 19 ± 3 s and 41.5 ± 4 s, respectively (Fig. 4A). Web10 apr. 2024 · 30 participants who accepted ICI treatment will receive next generation imaging including MRF and MR Relaxometry and hyperpolarized 13C pyruvate DNP …
Hyperpolarized MRI – An update and future perspectives
Web11 sep. 2024 · Among the hyperpolarized substrates that can be used for metabolic studies, [1-13 C]pyruvate gained much attention because its fast metabolic transformation into lactate can give relevant ... Web31 mrt. 2024 · Moreno KX, Moore CL, Burgess SC, Sherry AD, Malloy CR, Merritt ME. Production of hyperpolarized 13CO2 from [1-13C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production. Metabolomics. 2015 Oct;11(5):1144-1156. doi: 10.1007/s11306-014-0768-1. Epub 2015 Jan 9. hairdressers front st chester le street
Synthesis of 13C and 2H Labeled Vinyl Pyruvate and …
Web21 jan. 2024 · Carbon-13 MRI was used to assess exchange of hyperpolarized 13 C label between injected [1-13 C]pyruvate and the endogenous tumor lactate pool in breast cancer patients. Higher levels of 13 C label exchange were observed in more-aggressive tumors, including all triple-negative cancers. The 13 C label exchange correlated significantly … Web29 jul. 2024 · Hyperpolarized pyruvate is a highly promising tracer for in vivo metabolic MRI. A new synthetic approach provides access to the key precursor of 13 C labeled … Web31 mrt. 2024 · Jin ES, Moreno KX, Wang JX, Fidelino L, Merritt ME, Sherry AD, Malloy CR. Metabolism of hyperpolarized [1-(13)C]pyruvate through alternate pathways in rat liver. NMR Biomed. 2016 Apr;29(4):466-74. doi: 10.1002/nbm.3479. Epub 2016 Feb 2. hairdressers forestside