2024 Phenotypically modulated

Phenotypically modulated

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August undefined, 2024

WebFeb 11, 2024 · Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female … WebFeb 11, 2024 · Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female versus male plaques is unknown. Here, we show sex-stratified gene regulatory networks (GRNs) from human carotid atherosclerotic tissue.

Frontiers Revealing the Critical Regulators of Modulated Smooth ...

WebApr 1, 2009 · The phenotypic modulation of SMCs plays an important role in normal vascular development as well as the progression of vascular diseases such as atherosclerosis and … WebThe phenotype of the intimal SMCs gradually returned to the differentiated-type from the deep intima after 2 months, but a small number of the intimal SMCs remained in the dedifferentiated phenotype even at 6 months after the operation. login to tinkercad

KLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role …

WebAug 31, 2012 · Previous studies have shown that SMC phenotype is actively regulated via transduction of growth factor-mediated and biomechanical signals to the nucleus … WebJun 26, 2008 · Animal Model KLF5 is a transcription factor for Smemb/nonmuscle myosin heavy chain B, which is a molecular marker of phenotypically modulated smooth muscle cells. Normally, KLF5 is abundantly expressed in developing blood vessels, but is downregulated in adult vessels. WebDec 21, 2012 · Although the majority of studies of the phenotypic modulation of VSMCs has focused on the remodelling of blood vessels during disease or injury, little is known about … inexpensive cheap retaining wall

Identification of Phenotypically Modulated SMCs within …

SMC Derived Hyaluronan Modulates Vascular SMC-Phenotype in …

WebApr 25, 2024 · During aneurysm formation, smooth muscle cells undergo a process known as phenotypic modulation. Although this process has been well-studied, the possible role … WebJan 13, 2013 · We identified large numbers of phenotypically modulated SMCs in lesions that showed no detectible expression of MYH11 ( Fig. 4c) or ACTA2 ( Fig. 4d) and were identifiable as being of SMC origin... inexpensive cheap wood ceiling ideasWebVICs express number of VSMC-specific proteins and display features of phenotypically modulated VSMCs with increased migratory abilities. VICs, therefore represent resident … inexpensive cheap privacy fence

"WebKLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role in Atherosclerotic Plaque Pathogenesis - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. " - Phenotypically modulated

Phenotypically modulated

WebJan 23, 2009 · An accumulation of these phenotypically modulated SMCs within the diseased vessel contributes to plaque formation and the consequent narrowing of the vascular lumen. Our laboratory has had a long-standing interest in unraveling the molecular mechanisms that contribute to the phenotypic modulation of SMCs to prevent or reduce … WebNov 8, 2024 · The root system architecture (RSA) of plants is highly dependent on the surrounding nutrient environment. The uptake of essential nutrients triggers various signaling cascades and fluctuations in plant hormones to elicit physical changes in RSA. These pathways may involve signaling components known as small signaling peptides …

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WebMay 23, 2024 · Methods: To perform an unbiased and systematic analysis of the molecular regulatory mechanism of phenotypic switching of SMCs during AS in mice, we searched … WebApr 25, 2024 · The effects of smooth muscle cell apoptosis and necrosis accompanied by extracellular matrix degradation is believed to be the major processes leading to the weakening of the aortic wall and could be one of the major causes of AAA rupture; however, the mechanisms that regulate AAA rupture remain unknown (Henderson et al. 1999; …

WebMay 18, 2015 · Shown are phenotypically modulated SMCs (YFP + ACTA2 − cells highlighted in the white rectangle, b ), macrophage-like SMCs (YFP + ACTA2 − LGALS3 +, … WebFeb 8, 2024 · Differentially expression analysis revealed that, compared to Rgs5 low SMCs, Rgs5 high SMCs expressed significantly higher levels of molecular signatures for phenotypically modulated SMCs as ...

WebApr 15, 2014 · Studies within this dissertation are focused on identifying phenotypically modulated SMCs within atherosclerotic lesions using a newly developed conditional SMC specific lineage tracing mouse model, and a novel method that allows for the visualization of histone modifications of single genomic loci with single-cell resolution in formaldehyde ... WebFeb 25, 2015 · In intimal lesions, we observed 2 phenotypically distinct subtypes of SMCs: hyperchromatic and oval cells staining positive for αSMA, vimentin, SM1 and HHF35 but …

We tested the hypothesis that phenotypically modulated smooth …

WebSingle cell RNA sequencing (scRNA-Seq) identified phenotypically modulated SMCs (mSMCs) characterized by upregulation of macrophage, fibroblast, and chrondrocyte markers that appear with atherosclerotic plaque formation in Apoe-/- mice aortas. This transition is dependent on Kruppel-like factor 4 (Klf4). inexpensive cheer uniformsWebApr 4, 2024 · Preview PDF Abstract Objective: Vascular smooth muscle cells (VSMCs) are the primary contractile component of blood vessels and can undergo phenotypic … inexpensive cheese knivesWebJun 1, 2012 · Phenotypically modulated SMCs are characterized by a decreased expression of SMC-specific proteins and show a high degree of proliferation and the ability to … inexpensive chicken diy dog foodWebAug 1, 2024 · In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate, proliferate and migrate in a process known as phenotypic modulation. However, the phenotype of... inexpensive chef knivesWebFeb 25, 2015 · Assessment of phenotypically modulated smooth muscle cells SMCs in vascular lesions were immunophenotyped using two anti-SMC myosin heavy chain markers (SM1 and SM2) and three anti-actin markers (αSMA, HHF35, and CGA7). inexpensive chic minimalist handbagsWebMay 23, 2024 · Methods: To perform an unbiased and systematic analysis of the molecular regulatory mechanism of phenotypic switching of SMCs during AS in mice, we searched and included several publicly available single-cell datasets from the GEO database, resulting in an inclusion of more than 80,000 cells. inexpensive child care near meWebJan 1, 2024 · Phenotypic modulation Methods We summarize findings from extensive literature searches to highlight recent discoveries in the mechanisms underlying vascular smooth muscle cell (VSMC) phenotypic switching with particular relevance to intimal hyperplasia. PubMed was searched from January 2001 to December 2024. inexpensive chihuahua puppies for sale