2024 Slc13a3 and succinate

Slc13a3 and succinate

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August undefined, 2024

WebApr 28, 2024 · Below, we consider some of the cellular and physiologic adaptations that depend on succinate-driven superoxide production. Fig. 2: Succinate controls mitochondrial superoxide production through... WebSep 6, 2024 · Mechanistically, Slc13a3, a direct target of Slug in LSCs, restricts the self-renewal of LSCs and markedly prolongs recipient survival. Genetic or pharmacological inhibition of SLUG or forced...

SLC13A3 - Wikipedia

WebDec 20, 2024 · SLC13A3 (a sodium/dicarboxylate cotransporter) was detected in the intestinal organoids and demonstrated to transport succinate into ISCs, as confirmed by the contact of FITC-succinate with ISCs nucleus. WebJul 9, 2024 · To assess whether sodium-dependent SLC13A3 plays a role in the import of R-2-HG into T cells, we measured R-2-HG uptake under reduced sodium levels. Sodium starvation resulted in a 65% decrease... insulated panels for walls perth

SLC13 family of Na⁺-coupled di- and tri-carboxylate/sulfate

WebSep 6, 2024 · It has been reported that Slc13a3 is a Na + /dicarboxylate cotransporter and it is associated with the Krebs cycle occurring in mitochondrial matrix for transporting … WebJan 28, 2014 · This presentation will focus on the di- and tricarboxylate transporters, NaDC1 (SLC13A2), NaDC3 (SLC13A3) and NaCT (SLC13A5). The substrates of these transporters are metabolic intermediates of the citric acid cycle, including citrate, succinate and α-ketoglutarate, which can exert signaling effects through specific receptors or affect ... WebUseful information about the protein provided by UniProt. High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, including suc cinate, alpha-ketoglutarate and N-acetylaspartate 1. The stoichiometry is probably 3 Na (+) for 1 divalent succinate. job powell river

Sodium-coupled dicarboxylate and citrate transporters from

Pharos : Target Details - SLC13A3 - National Institutes of Health

WebSLC13A3 Antibody (PA5-53224) in IHC Immunohistochemical staining of SLC13A3 in human kidney tissue shows strong cytoplasmic and membranous positivity in tubular cells. Samples were probed using a SLC13A3 Polyclonal Antibody ( Product # PA5-53224 ). Product Details Product Specific Information WebJan 1, 2024 · In mouse bone marrow-derived macrophages (BMDMs), succinate acts as a stabilizing signal for the transcription factor hypoxia-inducible factor 1 alpha (HIF-1 α) via prolyl hydroxylases enzyme (PHD) inhibition, to induce transcription of interleukin (IL)-1β and drive a proinflammatory phenotype [3 ]. insulated panels for freezer jobpower construction software

"WebAug 18, 2024 · The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter, plays a key role in importing citrate from the circulation into liver cells. Recent … " - Slc13a3 and succinate

Slc13a3 and succinate

Discovery and characterization of novel inhibitors of the sodium ...

WebOct 12, 2024 · Background Tumors display a high rate of glucose metabolism and the SLC2A (also known as GLUT) gene family may be central regulators of cellular glucose … WebApr 1, 2013 · The SLC13 family comprises five genes ( SLC13A1, SLC13A2, SLC13A3, SLC13A4, and SLC13A5) encoding structurally related multi-spanning transporters (8–13 transmembrane domains) with orthologues found in prokaryotes and eukaryotes.

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WebSep 1, 2024 · NaDC3 (encoded by SLC13A3) has a broader tissue distribution and higher substrate affinity than NaDC1. Single-nucleotide polymorphisms of SLC13A3 are linked to … WebDec 8, 2024 · Slc13a3 solute carrier family 13 member 3 [ (Norway rat)] Gene ID: 64846, updated on 8-Dec-2024 Summary Enables carboxylic acid transmembrane transporter activity. Involved in aspartate transmembrane transport; citrate transport; and succinate transmembrane transport. Located in membrane. Is integral component of membrane.

WebMar 1, 2024 · This succinate-licensed anti-inflammatory function of iNSCs/NSCs is mediated by the secretion of prostaglandin (PG) E2, as well as by considerable scavenging of extracellular succinate. Loss of Sucnr1 function in NSCs leads to significantly reduced anti-inflammatory activities in vitro and in vivo after transplantation in EAE. WebObjective: SLC13A3 encodes the plasma membrane Na + /dicarboxylate cotransporter 3, which imports inside the cell 4 to 6 carbon dicarboxylates as well as N-acetylaspartate …

WebMammalian INDY (mINDY, NaCT, gene symbol SLC13A5) is a potential target for the treatment of metabolically associated fatty liver disease (MAFLD). This study evaluated the effects of a selective, cross-species active, non-competitive, non-substrate-like inhibitor of NaCT. First, the small molecule inhibitor ETG-5773 was evaluated for citrate and … WebAug 10, 2024 · Hence to reabsorb succinate across epithelial cell membranes, SLC13 transporters mediate succinate influx, and the organic anion transporters (OATs) mediate …

WebJan 5, 2024 · Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 [ (house mouse)] Gene ID: 114644, updated on 5-Jan-2024 Summary Enables high-affinity sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in succinate transmembrane transport.

WebThe SLC13 family comprises five genes (SLC13A1, SLC13A2, SLC13A3, SLC13A4, and SLC13A5) encoding structurally related multi-spanning transporters (8-13 transmembrane … insulated panel systems factoriesWebThe sodium-dependent dicarboxylate transporter SLC13A3 and citrate transporter SLC13A5 are also described to transport succinate in macrophages (Peruzzotti-Jametti et al., … insulated panel storeWebJan 5, 2024 · Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 [ (house mouse)] Gene ID: 114644, updated on 5-Jan-2024. … job powerpoint presentation exampleWebSample was probed with a SLC13A3 polyclonal antibody (Product # PA5-69137) at a dilution of 4.0-8.0 µg/mL. Images were taken at 400x magnification. ... Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. jobpower tax factorsWebMammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and … insulated panels for shedWebJan 11, 2024 · Functional studies performed on HEK293T cells transiently transfected with wild-type and mutant SLC13A3 indicated that the missense mutations caused a marked reduction in the capacity to transport αKG, succinate, and NAA. Interpretation. SLC13A3 deficiency causes acute and reversible leukoencephalopathy with marked accumulation … jobpower ebenthalWebJan 1, 2012 · The SLC13 gene family is comprised of structurally related membrane transport proteins with unique substrate specificities (Markovich, 2001; Markovich & Murer, 2004).They can be divided into the following two distinct groups: the Na +-sulfate (NaS) cotransporters and the Na +-carboxylate (NaC) cotransporters (Table 1).This review will … jobpower scandinavia ab